Eosinophilic Granuloma of the Tongue in a Cat

Introduction. Recently, there has been a large number of oral diseases in cats. Eosinophilic granuloma (EG) of the oral cavity may be a single lesion or occur simultaneously with other forms of the eosinophilic granuloma complex (CEG). The purpose of this article is to describe a clinical case of eosinophilic granuloma of the tongue in a cat and the possibility of effective treatment with prednisone.

Description of a clinical case. The article presents a clinical case of EG of the tongue in a cat, which also showed symptoms of itching, cutaneous erythema, as well as skin EG a few days after the formation of a tongue granuloma. The diagnosis of EG of the tongue was based on the data of anamnesis, clinical examination, cytological examination. Cytological examination revealed eosinophilic inflammation of the nodular formation on the tongue. During prednisone therapy at a dose of 2 mg / kg after a week, a significant decrease in the volume of the EG tongue was noted, then the dose was gradually reduced. The full course of prednisone therapy was 5 weeks until the symptoms completely disappeared.

Discussion. According to literature data, allergic factors (flea dermatitis, food allergy and non-food hypersensitivity) can be the causes of EG of the tongue. The symptoms may occur simultaneously with or without skin symptoms. In our case, the manifestation of itching, erythema of the skin appeared a few days after the formation of an eosinophilic plaque on the tongue. Prednisone can be used as therapy for oral hypertension, with starting doses ranging from 2 to 4 mg/kg per day. In our case, the starting dose of prednisone 2 mg / kg day, followed by a gradual dose reduction, had a pronounced therapeutic effect.

Conclusion. The treatment results and photographic materials provided in the article, demonstrating the manifestations of EH in the oral cavity, are useful for practicing specialists: a general veterinarian, dentist, oncologist, dermatologist, including in the differentiation of tumor and non-tumor lesions of the tongue. The importance of using cytological examination for the diagnosis of EH is shown. The use of prednisone has shown efficacy in the treatment of EG tongue.

1. Anderson JG, Hennet Ph. Management of Severe Oral Inflammatory Conditions in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice. 2022;52(1):159–184. https://doi.org/10.1016/j.cvsm.2021.09.008

2. Buckley L, Nuttall T. Feline Eosinophilic Granuloma Complex. Some clinical clarification. Journal of Feline Medicine & Surgery. 2012;14(7):471–481. https://doi.org/10.1177/1098612x12451549

3. Brilhante-Simões P, Delgado L, Martins Â. Association Between Cytological and Histopathological Diagnoses of Neoplastic and Non-Neoplastic Lesions in Oral Cavity from Dogs and Cats: An Observational Retrospective Study of 103 Cases. Veterinary Sciences. 2025;12(2):75. https://doi.org/10.3390/vetsci12020075

4. Falcão F, Faísca P, Viegas I. Feline oral cavity lesions diagnosed by histopathology: a 6-year retrospective study in Portugal. Journal of Feline Medicine and Surgery. 2020;22(10):977–983 https://doi.org/10.1177/1098612X19900033

5. Wechsler ME, Munitz A, Ackerman SJ, Drake MG. Eosinophils in Health and Disease: A State-of-the-Art Review. Mayo Clin Proc. 2021;96(10):2694–2707. https://doi.org/10.1016/j.mayocp.2021.04.025

6. Riker J, Rissi DR. A retrospective study of lingual lesions in 793 dogs and 406 cats at the Athens Veterinary Diagnostic Laboratory, 2010–2020. Journal of Veterinary Diagnostic Investigation. 2025;37(1):176–183. https://doi.org/10.1177/10406387241278888

7. Hopke KP, Sargent SJ. Novel presentation of eosinophilic granuloma complex in a cat. Journal of Feline Medicine and Surgery Open Reports. 2019;5(2). https://doi.org/10.1177/2055116919891548

8. Bhagirathi L, Madhusudan A, Shakir A. Traumatic ulcerative granuloma with stromal eosinophilia. Journal of Oral and Maxillofacial Pathology. 2021;(Suppl 1):S42–S45.https://doi.org/10.4103/jomfp.jomfp_321_20

9. William H. Miller, Craig E. Griffin, Karen L. Campbell. Muller & Kirk’s Small Animal Dermatology. 7th ed. St. Louis, Missouri: Elsevier; 2013.

10. Добсон Джейн М., Мелланби Ричард, Бейкон Николас. Онкология собак. Практика ветеринарного врача. Москва: Аквариум-Принт; 2017. 448 с.

11. Wei Y, Zeng Q, Gou H. Update on feline calicivirus: viral evolution, pathogenesis, epidemiology, prevention and control. Frontiers in Microbiology. 2024;15:1388420. https://doi.org/10.3389/fmicb.2024.1388420

12. Mueller RS, Nuttall T, Prost Ch. Treatment of the feline atopic syndrome - a systematic review. Veterinary Dermatology. 2021;32(1):43–e8. https://doi.org/10.1111/vde.12933

13. Halliwell R, Pucheu-Haston С, Olivry T, Prost C. Feline allergic diseases: introduction and proposed nomenclature. Veterinary Dermatology. 2021;32(1):8–e2. https://doi.org/10.1111/vde.12899

14. Feldman EC. Canine and Feline Endocrinology. 4th ed. USA; 2015. 696 pp.